Abstract. Four major sources of inertia-gravity waves are known in the Earth atmosphere: upper-tropospheric jet-streams, lower-tropospheric fronts, convection and topography. The Andes Cordillera region is an area where all of these major sources are potentially present. By combining ECMWF and NCEP-NCAR reanalysis, satellite and radiosoundings data and mesoscale WRF simulations in the Andes Cordillera region, we were able to identify the cases where, respectively, the jet-stream source, the convective source and the topography source are predominantly in action. We retrieve emitted wave parameters for each case, compare them, and analyse possible emission mechanisms. The WRF mesoscale model shows very good performance in reproducing the inertia-gravity waves identified in the data analysis, and assessing their likely sources.